This paper is a comparative study between Francis Bacon's The New Atlantis and William Blake's The Book of Urizen. The researchers will examine the two writers' views about science and its impact over two different epochs. In this respect, methods and forms of acquiring knowledge will be scrutinized to reveal how different these authors are in their definitions of scientific thought. The researchers will also show how the notion of progress helps shape method and form in each work. The aim is to illustrate the two dominant attitudes towards science in the seventeenth and the nineteenth centuries and the way these outlooks influenced literature in each era.